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Terms of Use


The material contained within the Hilser Lab's BEST Online Services is copyright unless stated otherwise.

Available for Academic & not-for-profit Uses Only

This site is restricted to not-for-profit uses only. The COREX/BEST web tools perform two functions: 1) a statistical thermodynamic ensemble is generated from a user supplied PDB file, and 2) various user-specified structural-energetic properties of the ensemble are calculated. All of the ensembles calculated from PDB files will become part of the COREX/BEST database, which will ultimately become public domain.

Much of the material provided on the online services may be reproduced free of charge for educational non-commercial purposes provided that the source is acknowledged and that it is reproduced accurately and not used in a misleading context. This permission does not extend to any material on the websites that is identified as being the copyright of a third party. You must obtain authorization to reproduce such material from the copyright holders concerned.

Should you wish to re-publish (as opposed to photocopy) any of the Hilser Lab's BEST Online Services copyright material on any of the online services please contact us to obtain permission.


Hilser Lab's BEST Online Services seeks to ensure that the information published on its online services is up-to-date and accurate. However, the information on the websites does not constitute legal or professional advice and Hilser Lab's BEST Online Services cannot accept any liability for actions or consequences arising from its use. Hilser Lab's BEST Online Services cannot be held responsible for the contents of any other website accessed through a link on our site. Hilser Lab's BEST Online Services provides these services as a convenience and inclusion of a service does not imply endorsement by Hilser Lab's BEST Online Services of an external site.

Your Privacy

Hilser Lab's BEST Online Services recognizes that your privacy is important to you. Hilser Lab's BEST Online Services is committed to respecting online privacy. We will apply appropriate protection and management of any personally identifiable information you share with us. We will not pass on your details to any third party.


If you publish results obtained from this web interface, please acknowledge the following publications:

  • Vertrees J., Barritt P., Whitten S., and V. J. Hilser. COREX/BEST server: a web browser-based program that calculates regional stability variations within protein structures. (2005) Bioinformatics. 21: 3318-3319.
  • Hilser, V.J., and E. Freire. (1996) Structure Based Calculation of the Equilibrium Folding Pathway of Proteins. Correlation with Hydrogen Exchange Protection Factors. J. Mol. Biol. 262: 756-772.
  • Hilser, V. J., Garcia-Moreno E., B., Oas, T. G., Kapp, G., Whitten, S. T. (2006). A Statistical Thermodynamic Model of the Protein Ensemble. Chem. Rev., 106(5), 1545-1558.
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